MEDICINAL CHEMISTRY – II STUDY MATERIAL - NOTES PDF free download | B pharmacy 3rd year - 5th sem

 MEDICINAL CHEMISTRY – II STUDY MATERIAL - NOTES PDF free download 

scroll down below to download

Scope: 

  This subject is designed to impart fundamental knowledge on the structure, chemistry and therapeutic value of drugs. The subject emphasizes on structure activity relationships of drugs, importance of physicochemical properties and metabolism of drugs. The syllabus also emphasizes on chemical synthesis of important drugs under each class.

Sallybus :-

UNIT- I :-

Antihistaminic agents: 

 Histamine, receptors and their distribution in the humanbody H1–antagonists: Diphenhydramine hydrochloride*, Dimenhydrinate, Doxylamines cuccinate, Clemastine fumarate, Diphenylphyraline hydrochloride, Tripelenamine hydrochloride, Chlorcyclizine hydrochloride, Meclizine hydrochloride, Buclizine hydrochloride, Chlorpheniramine maleate, Triprolidine hydrochloride*, Phenidamine tartarate, Promethazine hydrochloride*, Trimeprazine tartrate, Cyproheptadine hydrochloride, Azatidine maleate, Astemizole, Loratadine, Cetirizine, Levocetrazine Cromolyn sodium 

 H2-antagonists: 

Cimetidine*, Famotidine, Ranitidin. Gastric Proton pump inhibitors: Omeprazole, Lansoprazole, Rabeprazole, Pantoprazole Anti-neoplastic agents: Alkylating agents: Meclorethamine*, Cyclophosphamide, Melphalan Chlorambucil, Busulfan, Thiotepa

 Antimetabolites: 

Mercaptopurine*, Thioguanine, Fluorouracil, Floxuridine, Cytarabine, Methotrexate*, Azathioprine

 Antibiotics:

 Dactinomycin, Daunorubicin, Doxorubicin, Bleomycin Plant products: Etoposide, Vinblastin sulphate, Vincristin sulphate

 Miscellaneous:

 Cisplatin, Mitotane. 

UNIT – II 

Anti-anginal: 

Vasodilators: Amyl nitrite, Nitroglycerin*, Pentaerythritol tetranitrate, Isosorbide dinitrite*, Dipyridamole. 

Calcium channel blockers: 

Verapamil, Bepridil hydrochloride, Diltiazem hydrochloride, Nifedipine, Amlodipine, Felodipine, Nicardipine, Nimodipine. 

 Diuretics: 

Carbonic anhydrase inhibitors: Acetazolamide*, Methazolamide, Dichlorphenamide. 

Thiazides: 

Chlorthiazide*, Hydrochlorothiazide, Hydroflumethiazide, Cyclothiazide, 

Loop diuretics: Furosemide*, Bumetanide, Ethacrynic acid. 

 Potassium sparing Diuretics: Spironolactone, Triamterene, Amiloride. Osmotic Diuretics: Mannitol 

Anti-hypertensive Agents:

 Timolol, Captopril, Lisinopril, Enalapril, Benazepril hydrochloride, Quinapril hydrochloride, Methyldopate hydrochloride,* Clonidine hydrochloride, Guanethidine monosulphate, Guanabenz acetate, Sodium nitroprusside, Diazoxide, Minoxidil, Reserpine, Hydralazine hydrochloride. 

UNIT- III 

Anti-arrhythmic Drugs:

 Quinidine sulphate, Procainamide hydrochloride, Disopyramide phosphate*, Phenytoin sodium, Lidocaine hydrochloride, Tocainide hydrochloride, Mexiletine hydrochloride, Lorcainide hydrochloride, Amiodarone, Sotalol. 

Anti-hyperlipidemic agents: 

Clofibrate, Lovastatin, Cholesteramine and Cholestipol Coagulant & Anticoagulants: Menadione, Acetomenadione, Warfarin*, Anisindione, clopidogrel 

 Drugs used in Congestive Heart Failure:

 Digoxin, Digitoxin, Nesiritide, Bosentan, Tezosentan. 

UNIT- IV

Drugs acting on Endocrine system

 Nomenclature, Stereochemistry and metabolism of steroids 

Sex hormones: 

 Testosterone, Nandralone, Progestrones, Oestriol, Oestradiol, Oestrione, Diethyl stilbestrol. 

Drugs for erectile dysfunction: 

Sildenafil, Tadalafil. 

Oral contraceptives: 

Mifepristone, Norgestril, Levonorgestrol

 Corticosteroids: 

Cortisone, Hydrocortisone, Prednisolone, Betamethasone, Dexamethasone

 Thyroid and antithyroid drugs:

 L-Thyroxine, L-Thyronine, Propylthiouracil, Methimazole. 

UNIT – V 

Antidiabetic agents:

 Insulin and its preparations Sulfonyl ureas: Tolbutamide*, Chlorpropamide, Glipizide, Glimepiride. 

Biguanides: 

Metformin. Thiazolidinediones: Pioglitazone, Rosiglitazone. Meglitinides: Repaglinide, Nateglinide. 

Glucosidase inhibitors: 

Acrabose, Voglibose. 

 Local Anesthetics: 

SAR of Local anesthetics Benzoic Acid derivatives; Cocaine, Hexylcaine, Meprylcaine, Cyclomethycaine, Piperocaine. 

Amino Benzoic acid derivatives: 

Benzocaine*, Butamben, Procaine*, Butacaine, Propoxycaine, Tetracaine, Benoxinate.

 Lidocaine/Anilide derivatives: 

Lignocaine, Mepivacaine, Prilocaine, Etidocaine. Miscellaneous: Phenacaine, Diperodon, Dibucaine.

Download Medicinal chemistry notes by clicking below... 

Medicinal chemistry – II - Theory Notes pdf download

Medicinal chemistry - 2 - theory study material pdf download