Pharmaceutical Organic Chemistry 3 | Study material | Notes | Books | Pdf | free Download | B pharmacy 4th sem

Pharmaceutical Organic Chemistry 3 | Study material | Notes | Books | Pdf | free Download | B pharmacy :-

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Pharmaceutical organic chemistry 3

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Pharmaceutical Organic Chemistry 3 Sallybus :-

UNIT-I 

Stereo isomerism :

Optical isomerism – 

Optical activity, enantiomerism, diastereoisomerism, meso compounds Elements of symmetry, chiral and achiral molecules 

DL system of nomenclature of optical isomers, sequence rules, RS system of nomenclature of optical isomers

 Reactions of chiral molecules 

Racemic modification and resolution of racemic mixture. 

Asymmetric synthesis: partial and absolute.

UNIT-II

Geometrical isomerism :

Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems) 

Methods of determination of configuration of geometrical isomers. 

Conformational isomerism in Ethane, n-Butane and Cyclohexane. 

Stereo isomerism in biphenyl compounds (Atropisomerism) and conditions for optical activity. 

Stereospecific and stereoselective reactions.

UNIT-III   

Heterocyclic compounds : 

Nomenclature and classification 

Synthesis, reactions and medicinal uses of following compounds/derivatives Pyrrole, Furan, and Thiophene 

Relative aromaticity and reactivity of Pyrrole, Furan and Thiophene . 

UNIT-IV 

Synthesis, reactions and medicinal uses of following compounds/derivatives 

Pyrazole, Imidazole, Oxazole and Thiazole. Pyridine, Quinoline, Isoquinoline, Acridine and Indole. 

Basicity of pyridine Synthesis and medicinal uses of Pyrimidine, Purine, azepines and their derivatives . 

UNIT-V

Reactions of synthetic importance :

Metal hydride reduction (NaBH4 and LiAlH4), Clemmensen reduction, Birch reduction, Wolff Kishner reduction. 

Oppenauer-oxidation and Dakin reaction. Beckmanns rearrangement and Schmidt rearrangement. 

Claisen-Schmidt condensation . 

 Recommended Books for Pharmaceutical Organic Chemistry 3 (Latest Editions) :-

1. Organic chemistry by I.L. Finar, Volume-I & II.

2. A text book of organic chemistry – Arun Bahl, B.S. Bahl. 

3. Heterocyclic Chemistry by Raj K. Bansal 

4. Organic Chemistry by Morrison and Boyd 

5. Heterocyclic Chemistry by T.L. Gilchrist