Physical Pharmaceutics I - Theory | Study material | Notes | Books |free pdf | B Pharmacy 3rd sem

Physical Pharmaceutics I - Theory | Study material | Notes | Books |free pdf | B Pharmacy 3rd sem :-

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1- PHYSICAL PHARMACEUTICS-I (Theory) notes

2- PHYSICAL PHARMACEUTICS-I (Theory) books

3- PHYSICAL PHARMACEUTICS-I (Theory)  study material


Physical Pharmaceutics I - Theory Sallybus :-

Scope:

The course deals with the various physica and physicochemical properties, and principles involved in dosage forms/formulations.
Theory and practical components of the subject help the student to get a better insight into various areas of formulation research and development, and stability studies of pharmaceutical dosage forms.

 Objectives:

Upon the completion of the course student shall be able to
1. Understand  various  physicochemical  properties  of  drug  molecules  in  the designing the dosage forms
2. Know the principles of chemical kinetics & to use them for stability testing nad determination of expiry date of formulations
 3. Demonstrate use of physicochemical properties in the formulation development and evaluation of dosage forms.

 Course Content:

UNIT-I 10 Hours

Solubility of drugs: Solubility expressions, mechanisms of solute solvent interactions, ideal solubility parameters, solvation & association, quantitative approach to the factors influencing  solubility of  drugs,  diffusion  principles  in biological systems. Solubility of gas in liquids, solubility of liquids in liquids, (Binary solutions, ideal solutions) Raoult’s law, real solutions. Partially miscible liquids, Critical solution temperature and applications. Distribution law, its limitations and applications.

 UNIT-II 10Hours

States of Matter and properties of matter:State of matter, changes in the state of matter, latent heats, vapour pressure, sublimation critical point, eutectic mixtures, gases, aerosols –  inhalers,  relative  humidity,  liquid  complexes,  liquid  crystals,  glassy states,  solid- crystalline, amorphous & polymorphism.  Physicochemical  properties  of  drug  molecules:  Refractive  index,  optical  rotation, dielectric constant, dipole moment, dissociation constant, determinations and applications.

UNIT-III 08 Hours

Surface and interfacial phenomenon: Liquid interface, surface & interfacial tensions,   surface free energy, measurement of surface & interfacial tensions, spreading coefficient, adsorption at  liquid interfaces, surface active agents, HLB Scale, solubilisation, detergency, adsorption at solid interface.

UNIT-IV 08Hours

Complexation and protein binding: Introduction, Classification of Complexation, Applications, methods of analysis, protein binding, Complexation and drug action, crystalline structures of complexes and thermodynamic treatment of stability constants.

UNIT-V 07 Hours

 pH, buffers and Isotonic solutions: Sorensen’s pH scale, pH determination (electrometric and calorimetric), applications of buffers, buffer equation, buffer capacity, buffers in pharmaceutical and biological systems, buffered isotonic solutions.